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Physical inactivity is the fourth leading cause of global mortality. Health organizations have requested a tool to objectively measure physical activity. Respirometry and doubly labeled water accurately estimate energy expenditure, but are infeasible for everyday use. Smartwatches are portable, but have significant errors. Existing wearable methods poorly estimate time-varying activity, which comprises 40% of daily steps. Here, we present a Wearable System that estimates metabolic energy expenditure in real-time during common steady-state and time-varying activities with substantially lower error than state-of-the-art methods. We perform experiments to select sensors, collect training data, and validate the Wearable System with new subjects and new conditions for walking, running, stair climbing, and biking. The Wearable System uses inertial measurement units worn on the shank and thigh as they distinguish lower-limb activity better than wrist or trunk kinematics and converge more quickly than physiological signals. When evaluated with a diverse group of new subjects, the Wearable System has a cumulative error of 13% across common activities, significantly less than 42% for a smartwatch and 44% for an activity-specific smartwatch. This approach enables accurate physical activity monitoring which could enable new energy balance systems for weight management or large-scale activity monitoring.

 

Surgeries involving interaction with soft tissue like the brain need to minimize shear and normal forces that can cause tissue damage or hemorrhage. Other surgeries require the ability to follow a complex, curved path, such as through an intestine or to a kidney stone. This paper presents a soft catheter that has the potential to aid in these challenging cases. The soft catheter is capable of apical extension in which the tip extends while the rest of the catheter remains stationary. This limits shear forces with the environment, easing movement of a body's tip through a constrained space. The soft catheter is pre-formed to patient-specific trajectories, meaning that normal forces against tissue would only arise due to errors between the actual and desired paths; we show decrease in normal force applied to the environment on the order of 100 compared to a standard catheter in a 30 degree bend. Setting the internal pressure allows for control of catheter stiffness, with a 500 times difference over the range of tested pressures. Manual operation to reach a surgical site requires only holding the correct orientation at the entry point into the body and setting the internal pressure of the catheter. This soft catheter could offer two benefits: the ability to apply low tissue interaction forces and reach challenging locations within the body.